Caspase-6 (CASP6) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ICC/IF, IHC, IP, WB |
|---|---|
| Recommended Dilution | Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation: 1:50-1:200, Western Blot: 1:1000-1:2000, Immunohistochemistry-Paraffin: 1:1000-1:5000, Immunohistochemistry-Frozen |
| Reactivity | Canine, Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Recombinant catalytically active human Caspase-6 protein was used as immunogen. |
| Buffer | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Concentration | lot specific |
| Purification | Whole antisera |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | caspase 6 |
| Database Link | |
| Background | Caspases belong to the cysteine-aspartic acid protease (Caspase) family which plays a major role in the transduction of the apoptotic signal and execution of apoptosis in mammalian cells. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream. Caspase 3 (CPP32) and Caspase 6 (Mch2) are the major active caspases in apoptotic cells, and are activated in response to distinct apoptosis-inducing stimuli and in all cell lines analyzed. Both CPP32 and Mch2 are present in apoptotic cells as multiple active species. Caspase-6 cleaves nuclear mitotic apparatus protein (NuMA) and mediates the shrinkage and fragmentation of nuclei. |
| Synonyms | MCH2 |
| Note | Immunohistochemistry (frozen): Users should optimize according to model and immunodetection system used (secondary reagents) Immunocytochemistry/Immunofluorescence was reported in scientific literature. |
| Reference Data | |
| Protein Categories | Enzyme: Peptidases, Intracellular Proteins |
| Protein Families | Druggable Genome, Protease, Stem cell - Pluripotency |
| Protein Pathways | Apoptosis |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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