OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

TRPC1 Rabbit Polyclonal Antibody

Be the first to review this product
SKU
TA328677
Rabbit Polyclonal Anti-TRPC1
Size:
50 ul
Conjugation:
Unconjugated
  $1,145.00
3 Weeks*
Bulk/Customize

Frequently Bought Together (2)

TA811000S beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control 30 ul
$200.00
LY418779 Transient overexpression lysate of transient receptor potential cation channel, subfamily C, member 1 (TRPC1) (as WB positive control) 100 ug
$665.00

View other "TRPC1 or NM_003304" antibodies

Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Peptide QLYDKGYTSKEQKDC, corresponding to amino acid residues 557-571 of human TRPC1.Intracellular.
Buffer Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Gene Name transient receptor potential cation channel subfamily C member 1
Database Link
Background The Transient Receptor Potential (TRP) superfamily is one of the largest ion channel families and consists of diverse groups of proteins. In mammals about 28 genes encode the TRP ion channel subunits. The mammalian TRP superfamily comprises six subfamilies known as the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipins), TRPP (polycystin) and the TRPA (ANKTM1) ion channels. The TRPC subfamily consists of seven proteins named TRPC1 to 7, which can be further divided into four subgroups based on their sequence homology and functional similarities: 1) TRPC1 2) TRPC4 and TRPC5 3) TRPC3, TRPC6, TRPC7 4) TRPC2. They are highly expressed in the central nervous system and to a lesser extent in peripheral tissues. TRPC1 was the first mammalian TRP protein that was reported to form an ion channel.2 It can co-assemble with other TRPC subunits (TRPC3, TRPC4, TRPC5) to form heterotetramers whose properties are distinct from that of their homomeric form. The existence of the TRPC1 homomers has not been established as yet. The TRPC1, TRPC4 and TRPC5 can be activated either by Ca2+ store depletion or by GPCR stimulation pathways, while TRPC3, TRPC6 and TRPC7 form non-selective cationic channels that are activated by the stimulation of GPCRs. TRPC1, 4 and TRPC5 are assumed to form components of store operated channels in some cell types such as salivary gland cells, endothelial cells and vascular smooth muscle cells.
Synonyms HTRP-1; TRP1
Reference Data
Protein Categories Membrane Proteins
Protein Families Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
Protein Pathways Calcium signaling pathway, Huntington's disease, Parkinson's disease
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Stanniocalcin2, A Promising New Target for Identifying Patients with Stroke/Ictus
Bermejo, López, Berna-Erro et al
Int J Mol Sci (2025) 26 (20) DOI: 10.3390/ijms26209999
Cited by 1
AI Summary: In this study, the OriGene polyclonal anti-TRPC1 antibody (SKU TA328677) was used to detect TRPC1 protein expression by Western blotting, contributing to the analysis of calcium channel alterations in platelets from stroke/ictus patients.
Snippet: , Madrid, Spain #08264) for 2 h (1:1000 in TBST);monoclonal anti-Orai3 antibody (Clone 1B4F1;Sigma-Aldrich , Madrid, Spain #SAB3500121) overnight (1:250 in TBST);polyclonal anti-TRPC1 antibody (Origene , Rockville, MD, USA # SKU TA328677) for 2 h (1:1000 in TBST);polyclonal anti-TRPC3 antibody (Abcam , Cambridge, UK #ab51560) overnight (1:1000 in TBST);polyclonal anti-TRPC6 antibody (Alo
FigureFigureFigure
WB IP
Stanniocalcin 2 Regulates Non-capacitative Ca2+ Entry and Aggregation in Mouse Platelets
López, Gómez-Gordo, Cantonero et al
Front Physiol (2018) 9, 266 DOI: 10.3389/fphys.2018.00266
Cited by 11
AI Summary: In this paper, OriGene products—including anti-Orai3 (Cat# TA322352), anti-TRPC3 (Cat# TA322366), and anti-TRPC6 (Cat# TA322368) antibodies—were used for Western blot analysis to assess the expression of calcium channels in mouse platelets, helping to reveal that Orai3 expression is enhanced in STC2-deficient mice.
FigureFigureFigure
Stanniocalcin 2 Regulates Non-capacitative Ca2+ Entry and Aggregation in Mouse Platelets
López, Gómez-Gordo, Cantonero et al
Front. Physiol. (2018) 9 DOI: 10.3389/fphys.2018.00266
AI Summary: OriGene contributed to this study by providing the rabbit polyclonal anti-TRPC1 antibody, which was used to investigate the role of TRPC1 in platelet Ca2+ entry mechanisms.
Snippet: Mouse anti-STIM1 [Clone 44 Clone 44-GOK (RUO)] antibody was from BD Biosciences (Madrid, Spain). Rabbit polyclonal anti-TRPC1 (against peptide QLYDKGYTSKEQKDC) antibody was supplied by OriGene (Rockville (MD) USA) Cached
Showing 1-3 of 3 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products