P2Y12 (P2RY12) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:100-1:3,000; FC: 1:50-1:600 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Peptide (C)KTTRPFKTSNPKNLLGAK,corresponding to amino acid residues 125-142 of human P2Y12 receptor.Intracellular, 2nd Cytoplasmic loop. |
| Buffer | Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
| Reconstitution Method | Add 50 ul double distilled water (DDW) to the lyophilized powder. |
| Purification | Affinity purified on immobilized antigen. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Gene Name | purinergic receptor P2Y12 |
| Database Link | |
| Background | The P2Y receptors belong to the G-protein coupled receptors superfamily. They mediate the actions of the extracellular nucleotides (ATP, ADP, UTP AND UDPA. Eight functional mammalian P2Y receptors have been described: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y14. The P2Y12 receptor is co-expressed with P2Y1 receptor on platelets leading to shape change, aggregation, and rise in intracellular Ca2+ upon activation. The only other expression of P2Y12 was found in brain, according to results of reverse transcription-polymerase chain reaction and northern blotting. The P2Y12 receptor has become a target for potential therapeutic drugs for the treatment of thromboembolism and other clotting disorders. |
| Synonyms | ADPG-R; BDPLT8; HORK3; P2T(AC); P2Y(12)R; P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; SP1999 |
| Reference Data | |
| Protein Categories | Cardiovascular diseases, GPCR, Membrane Proteins |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis
Pi, Mao, Chen et al
Autophagy (2020)
Pi, Mao, Chen et al
Autophagy (2020)
Cited by 203
Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release
Donner, Fälker, Gremer et al
Sci Signal (2016) 9 (429), ra52 DOI: 10.1126/scisignal.aaf6240
Donner, Fälker, Gremer et al
Sci Signal (2016) 9 (429), ra52 DOI: 10.1126/scisignal.aaf6240
Cited by 111
AI Summary: OriGene products contributed to this study by providing the P2RY12 shRNA (TL310792) and P2RY12 cDNA (RC208873) used to manipulate P2Y12 receptor expression in platelets, enabling the authors to investigate the role of P2Y12 signaling in amyloid-β-induced platelet activation and aggregation.
Showing 1-2 of 2 papers.
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