NFAT2 (NFATC1) Mouse Monoclonal Antibody [Clone ID: 7A6]
Specifications
| Product Data | |
| Clone Name | 7A6 |
|---|---|
| Application | WB |
| Recommended Dilution | WB, FC, IF |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Recombinant protein of human NFATc1 amino acids 197-304. |
| Buffer | This antibody is provided in phosphate-buffered solution, pH 7.2, 0.09% sodium azide. |
| Concentration | lot specific |
| Purification | The antibody was purified by affinity chromatography. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 101 kD |
| Gene Name | nuclear factor of activated T-cells 1 |
| Database Link | |
| Background | The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. The protein complex consists of NFAT1, NFAT2 (NFATc1 or NFATc), NFAT3, and NFAT4. All members of this family are transcription factors with a Rel homology domain and regulate gene transcription in concert with AP-1 (Jun/Fos) to orchestrate an effective immune response. NFAT proteins are predominantly expressed in cells of the immune system but are also expressed in skeletal muscle, keratinocytes and adipocytes, regulating cell differentiation programs in these cells. In resting cells, NFAT proteins are heavily phosphorylated and localized in the cytoplasm. Increased intracellular calcium concentrations activate the calcium/calmodulin-dependent serine phosphatase calcineurin, which dephosphorylates NFAT proteins, resulting in their subsequent translocation to the nucleus. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. |
| Synonyms | NF-ATC; NF-ATc1.2; NFAT2; NFATc |
| Reference Data | |
| Protein Categories | Cytokines, Growth Factors, Intracellular Proteins, Transciption Factors |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Axon guidance, B cell receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
NFAT5 regulates renal gene expression in response to Angiotensin II through Annexin-A2-mediated post-transcriptional regulation in hypertensive rats
Fähling, Paliege, Jönsson et al
Am. J. Physiol. Renal Physiol. (2018)
Fähling, Paliege, Jönsson et al
Am. J. Physiol. Renal Physiol. (2018)
Showing 1-1 of 1 papers.
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