Aqp4 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, WB |
|---|---|
| Recommended Dilution | WB 1:1000-4000, IF: 1:400 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | C-terminal peptide |
| Buffer | PBS pH7.4, 50% glycerol and 0.09% sodium azide |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | aquaporin 4 |
| Database Link | |
| Background | Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins .Aquaporin 4 is constitutively expressed in the basolateral cell membrane of princinpal collecting duct cells in the kidney and provide a pathway for water to exit these cells . It is also expressed in astrocytes and is upregulated by direct insult to the CNS . Aquaporin 4 has been propsed as the primary autoimmune target in neuromyelitis optica . |
| Synonyms | AQP-4; aquaporin-4; HMIWC2; MGC22454; MIWC; WCH4 |
| Note | Detects ~35kDa. May detect larger glycosylated bands ~50kDa. |
| Reference Data | |
Reviews
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Citations
Curcumin alleviates brain edema by lowering AQP4 expression levels in a rat model of hypoxia-hypercapnia-induced brain damage
Yu, Fan, Ye et al
Exp Ther Med (2016) 11 (3), 709-716 DOI: 10.3892/etm.2016.3022
Yu, Fan, Ye et al
Exp Ther Med (2016) 11 (3), 709-716 DOI: 10.3892/etm.2016.3022
Cited by 32
AI Summary: OriGene products contributed to this study by providing the AQP4 antibody (Cat# TA336295) and AQP4 primers (Cat# HQP019363), which were used to detect AQP4 protein and mRNA expression levels in rat brain tissues.
Showing 1-1 of 1 papers.
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