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Heme Oxygenase 1 (HMOX1) Mouse Monoclonal Antibody [Clone ID: 1F12-A6]

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SKU
TA326354
Mouse monoclonal HO-1 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $750.00
2 Weeks*
Bulk/Customize

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View other "Heme Oxygenase 1 or NM_002133" antibodies

Specifications
Specifications
Product Data
Clone Name 1F12-A6
Application WB
Recommended Dilution WB: 1:500-1000
Reactivity Bovine, Human, Mouse
Antibody Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Human HO-1 synthetic peptide, amino acids 1-30
Buffer PBS pH7.4, 50% glycerol
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name heme oxygenase 1
Database Link
Background Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin . These products have important physiological effects as carbon monoxide is a potent vasodilator; biliverdin and bilirubin are potent antioxidants; and the free iron increases oxidative stress and regulates the expression of many mRNAs .There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3; however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals . HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation . It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency , susceptibility to atherosclerotic lesion formation , endothelial cell injury, and growth retardation . Up-regulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress .
Synonyms bK286B10; HMOX1D; HO-1; HSP32
Note Detects a 32kDa protein, corresponding to the molecular mass of HO-1 on SDS Page immunoblots. Does not cross-react with HO-2
Reference Data
Protein Categories Chemokines, Cytokines, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, Transmembrane
Protein Pathways Porphyrin and chlorophyll metabolism
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Documents
Resources

file-alt Citations

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
Muliaditan, Caron, Okesola et al
Nat Commun (2018) 9 (1), 2951 DOI: 10.1038/s41467-018-05346-7
AI Summary: OriGene’s HO-1 antibody (mouse: EP1391Y) was used in this study to detect and analyze HO-1 protein expression in tumour-associated macrophages by western blot, contributing to the characterization of macrophage phenotypes involved in cancer metastasis.
Snippet: n 4T1 and E0771 tumours (Fig. 2j), which was expected since IL-24 is a known tumour suppressor gene33, inhibiting cell proliferation and migration in the wound healing context and thus preventing tumorigenesis34. Analysis of the microarray data for the FAP+ TAM population isolated from 4T1 tumours (Fig. 2a) revealed that these cells were also directly expressing some of the acute wound inflammat;C...
FigureFigureFigure
WB Array
Showing 1-1 of 1 papers.
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