Occludin (OCLN) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 200-1000 WB positive control: Human liver cancer tissue IHC: 15-50 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 266-522 amino acids of human occludin |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 59 kDa |
| Gene Name | occludin |
| Database Link | |
| Background | This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. |
| Synonyms | BLCPMG; PPP1R115 |
| Reference Data | |
| Protein Categories | Cytokines, Intracellular Proteins, Membrane Proteins, Nervous system Diseases |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Evaluation of the Antifibrotic Effects of Drugs Commonly Used in Inflammatory Intestinal Diseases on In Vitro Intestinal Cellular Models
Artone, Ciafarone, Augello et al
Int J Mol Sci (2024) 25 (16) DOI: 10.3390/ijms25168862
Artone, Ciafarone, Augello et al
Int J Mol Sci (2024) 25 (16) DOI: 10.3390/ijms25168862
Cited by 6
AI Summary: In this study, OriGene products—including anti-Occludin, anti-α-SMA (ACTA2), and anti-GAPDH antibodies—were used for Western blot and immunofluorescence analyses to assess fibrosis and EMT marker expression in evaluating the antifibrotic effects of drugs on intestinal cellular models.
Snippet: echnology, Pleasanton, CA, USA) 1:1000, rabbit monoclonal antibody anti-human phospho-SMAD2(Ser465/467)/SMAD3(Ser423/425) (Cell Signaling Technology) 1:1000, rabbit polyclonal antibody anti-OCCLUDIN (OriGene, Rockville, MA, USA) 1:1000, mouse monoclonal antibody anti-α-actin smooth muscle (ACTA2, α-SMA) (OriGene) 1:1000, and mouse monoclonal antibody anti-GAPDH (OriGene) 1:1000. Horseradish pero
Effects of shenling baizhu powder herbal formula on intestinal microbiota in high-fat diet-induced NAFLD rats
Zhang, Tang, Deng et al
Biomed Pharmacother (2018) 102, 1025-1036 DOI: 10.1016/j.biopha.2018.03.158
Zhang, Tang, Deng et al
Biomed Pharmacother (2018) 102, 1025-1036 DOI: 10.1016/j.biopha.2018.03.158
Cited by 121
AI Summary: In this study, OriGene’s TLR4 (TA506177) and MyD88 (TA327788) antibodies were used for western blot analysis to assess the expression of TLR4 pathway-related proteins in liver tissues, helping to elucidate the molecular mechanisms by which Shenling Baizhu powder alleviates NAFLD in rats.
Showing 1-2 of 2 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
