beta 2 Adrenergic Receptor (ADRB2) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 1000-2000 WB positive control: Hela and A549 cells IHC: 15-50 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 21-33 amino acids of Human adrenoceptor beta 2, surface |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 46 kDa |
| Gene Name | adrenoceptor beta 2 |
| Database Link | |
| Background | This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors; the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein; an adenylyl cyclase; cAMP-dependent kinase; and the counterbalancing phosphatase; PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms; point mutations; and/or downregulation of this gene are associated with nocturnal asthma; obesity and type 2 diabetes.? |
| Synonyms | ADRB2R; ADRBR; B2AR; BAR; BETA2AR |
| Reference Data | |
| Protein Categories | Allergies and autoimmune diseases, Cytokines, Endocrine and metabolic diseases, GPCR, Membrane Proteins |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Endocytosis, Neuroactive ligand-receptor interaction |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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