CMH1 (MYH7) Rabbit Polyclonal Antibody

SKU
TA323707
Anti-MYH7 Rabbit Polyclonal Antibody
  $305.00
In Stock*
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Specifications
Specifications
Product Data
Application IHC
Recommended Dilution IHC: 50-200
Positive control: Human gastric cancer
Predicted cell location: Cytoplasm
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to C terminal 300 amino acids of human myosin, heavy chain 7, cardiac muscle, beta
Buffer PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name myosin, heavy chain 7, cardiac muscle, beta
Database Link
Background Muscle myosin is a hexameric protein containing 2 heavy chain subunits; 2 alkali light chain subunits; and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy; myosin storage myopathy; dilated cardiomyopathy; and Laing early-onset distal myopathy.
Synonyms CMD1S; CMH1; MPD1; MYHCB; SPMD; SPMM
Reference Data
Protein Categories Cardiovascular diseases, Intracellular Proteins
Protein Pathways Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Tight junction, Viral myocarditis
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