Collagen II (COL2A1) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: Rat skeletal muscle tissue lysate IHC: 50-200 Positive control: Human liver cancer Predicted cell location: Secreted |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Full length fusion protein |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 30 kDa |
| Gene Name | collagen type II alpha 1 chain |
| Database Link | |
| Background | This gene encodes the alpha-1 chain of type II collagen; a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis; chondrodysplasia; early onset familial osteoarthritis; SED congenita; Langer-Saldino achondrogenesis; Kniest dysplasia; Stickler syndrome type I; and spondyloepimetaphyseal dysplasia Strudwick type. In addition; defects in processing chondrocalcin; a calcium binding protein that is the C-propeptide of this collagen molecule; are also associated with chondrodysplasia. There are two transcripts identified for this gene. |
| Synonyms | ANFH; AOM; COL11A3; SEDC; STL1 |
| Reference Data | |
| Protein Categories | Growth Factors, Nervous system Diseases, Secreated Proteins |
| Protein Pathways | ECM-receptor interaction, Focal adhesion |
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