Ubiquitin (UBB) Rabbit Polyclonal Antibody

SKU TA322285

Anti-UBB Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 200-1000; WB positive control: Hela cells and mouse liver tissue; IHC: 25-100; Positive control: Human thyroid cancer; Predicted cell location: Nucleus and Cytoplasm
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 102-229 amino acids of Human Polyubiquitin-B
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: ubiquitin B
• Database Link:
  NP_061828
  P0CG47
• Background: This gene encodes ubiquitin; one of the most conserved proteins known. Ubiquitin is required for ATP-dependent; nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded; and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation; suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently; the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.?
• Synonyms: HEL-S-50

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Parkinson's disease