SOCS1 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: HT-29 and 231 cells IHC: 100-300 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 199-211 amino acids of Human suppressor of cytokine signaling 1 |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 24 kDa |
| Gene Name | suppressor of cytokine signaling 1 |
| Database Link | |
| Background | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. |
| Synonyms | CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3 |
| Reference Data | |
| Protein Categories | Cytokines, Growth Factors, Immune system diseases, Intracellular Proteins |
| Protein Families | Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway |
| Protein Pathways | Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
HBeAg induces the expression of macrophage miR-155 to accelerate liver injury via promoting production of inflammatory cytokines
Wang, Bian, Li et al
Cell Mol Life Sci (2018) 75 (14), 2627-2641 DOI: 10.1007/s00018-018-2753-8
Wang, Bian, Li et al
Cell Mol Life Sci (2018) 75 (14), 2627-2641 DOI: 10.1007/s00018-018-2753-8
Cited by 61
AI Summary: In this study, OriGene's miR-155 mimic (Cat# miR10005594-1-5) and miR-155 inhibitor (Cat# miR20005594-1-5) were used to modulate miR-155 expression in macrophages, enabling the authors to demonstrate that miR-155 regulates HBeAg-induced inflammatory cytokine production.
Showing 1-1 of 1 papers.
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