Dopamine Receptor D1 (DRD1) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 1000-5000 WB positive control: Hela cells IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 10-23 amino acids of Human Dopamine receptor D1 |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 49 kDa |
| Gene Name | dopamine receptor D1 |
| Database Link | |
| Background | This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development; mediate some behavioral responses; and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. |
| Synonyms | DADR; DRD1A |
| Reference Data | |
| Protein Categories | GPCR, Growth Factors, Membrane Proteins |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Gap junction, Neuroactive ligand-receptor interaction |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Sorting nexin 1 loss results in increased oxidative stress and hypertension
Yang, Asico, Beitelshees et al
FASEB J. (2020)
Yang, Asico, Beitelshees et al
FASEB J. (2020)
AI Summary: OriGene contributed to this study by providing the D1R (dopamine D1 receptor) antibody, which was used for immunoblot analyses to examine protein expression relevant to the mechanisms underlying oxidative stress and hypertension in SNX1-deficient mice.
Snippet: Abstract Acute renal depletion of sorting nexin 1 (SNX1) in mice results in blunted natriuretic response and hypertension due to impaired dopamine D5 receptor (D5R) activity. We elucidated the mole...;The immunoreactive bands were visualized by chemiluminescence and autoradiography or the Odyssey Imaging System (LI‐COR Biosciences, Lincoln, NE). The primary antibodies were purchased from GeneTex (...
Showing 1-1 of 1 papers.
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