KCNK12 Rabbit Polyclonal Antibody

CAT#: TA319968

Rabbit Polyclonal KCNK12 Antibody

Product Images

Western blot analysis of KCNK12 in rat brain tissue lysate with KCNK12 antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of KCNK12 in mouse brain tissue with KCNK12 antibody at 5 ug/mL.

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  Immunofluorescence of KCNK12 in mouse brain tissue with KCNK12 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KCNK12 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human KCNK12.
• Formulation: KCNK12 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: KCNK12 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium two pore domain channel subfamily K member 12
• Database Link:
  NP_071338
  Entrez Gene 64119 RatEntrez Gene 210741 MouseEntrez Gene 56660 Human
  UniProt ID Q9HB15
• Background: KCNK12 Antibody: KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. KCNK12 is expressed mainly in the brain and lung, but also observed in the kidneys, heart and skeletal muscle. KCNK12 is closely related to KCNK13 (58% identity at the amino acid level), but could not yet been functionally expressed in vitro and may require other proteins to become active.
• Synonyms: K2p12.1; THIK-2; THIK2

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Potassium, Transmembrane