CP110 (CCP110) Rabbit Polyclonal Antibody

SKU TA319786

Rabbit Polyclonal CCP110 Antibody

Product Data

• Application: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 5 ug/mL
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CCP110 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human CCP110.
• Buffer: CCP110 Antibody is supplied in PBS containing 0.02% sodium azide.
• Purification: CCP110 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: centriolar coiled-coil protein 110kDa
• Database Link:
  NP_001185951
  O43303
• Background: CCP110 Antibody: CCP110 is a centrosomal protein required for the centrosome to function as a microtubule organizing center and plays an essential role in centrosome duplication. It is a target of cyclin-dependent kinases (CDKs); disruption of CCP110 phosphorylation leads to unscheduled centrosome separation and polyploidy. CCP110 is also a target of SCF (Cyclin F) ubiquitin ligase complex, leading to its degradation, suggesting that this complex controls centrosome homeostasis and mitotic fidelity through CCP110 degradation. The centriolar kinesin Kif24 also interacts with CP110 and remodel microtubules and regulate ciliogenesis.
• Synonyms: Cep110; CP110

Reference Data