Axin 2 (AXIN2) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | AXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2. The immunogen is located within amino acids 780 - 830 of AXIN2. |
| Buffer | AXIN2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | AXIN2 Antibody is affinity chromatography purified via peptide column. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | axin 2 |
| Database Link | |
| Background | AXIN2 Antibody: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. |
| Synonyms | AXIL; ODCRCS |
| Reference Data | |
| Protein Categories | Cancer: Brain and CNS, Cancer: Gastrointestinal, Intracellular Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
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Citations
Wnt signalling maintains self-renewal of human hepatoblasts without blocking their differentiation
Zacharis, Morell, Tomaz et al
Development (2025)
Zacharis, Morell, Tomaz et al
Development (2025)
Cited by 3
AI Summary: OriGene's FOXA3 antibody (TA319745) was used in this study to help identify and analyze hepatoblasts, contributing to the investigation of Wnt signalling in human liver development.
Showing 1-1 of 1 papers.
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