CD168 (HMMR) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 5 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | RHAMM antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human RHAMM. |
| Buffer | RHAMM Antibody is supplied in PBS containing 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | RHAMM Antibody is affinity chromatography purified via peptide column. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | hyaluronan mediated motility receptor |
| Database Link | |
| Background | RHAMM Antibody: The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability. |
| Synonyms | CD168; IHABP; RHAMM |
| Reference Data | |
| Protein Categories | Cancer: Gynecologic, CD Markers, Intracellular Proteins |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Protein Pathways | ECM-receptor interaction |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Targeting Long Noncoding RNA HMMR-AS1 Suppresses and Radiosensitizes Glioblastoma
Li, Ji, Wang
Neoplasia (2018) 20 (5), 456-466 DOI: 10.1016/j.neo.2018.02.010
Li, Ji, Wang
Neoplasia (2018) 20 (5), 456-466 DOI: 10.1016/j.neo.2018.02.010
AI Summary: In this study, the HMMR#1 product from OriGene was used to investigate the role of HMMR in glioblastoma, enabling the researchers to assess how targeting the long noncoding RNA HMMR-AS1 affects HMMR expression and glioblastoma progression.
Snippet: c-Myc, BMI1, p27 Kip1, Cyclin D1, CDK2, CDK4, ERK1/2, p-ERK1/2(Thr202/Tyr204), ZEB1, β-Catenin, N-Cadherin, Vimentin, ATM, p-ATM, and Rad51 were all purchased from Cell Signaling Technology (Beverly, MA);HMMR#1 was purchased from OriGene (Rockville
Showing 1-1 of 1 papers.
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