Collagen I (COL1A1) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 1:1000, IHC: 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to amino acid residues specific to the collagen 1, alpha 1 propeptide conjugated to KLH |
| Buffer | 100 ul in PBS |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 180 kDa |
| Gene Name | collagen type I alpha 1 |
| Database Link | |
| Background | This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. provided by R. Dalgleish |
| Synonyms | EDSC; OI1; OI2; OI3; OI4 |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins, Secreated Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | ECM-receptor interaction, Focal adhesion |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Identification of anti-fibrotic and pro-apoptotic bioactive compounds from Ganoderma formosanum and their possible mechanisms in modulating TGF-β1-induced lung fibrosis
Cheng, Chong, Hsieh et al
J Ethnopharmacol (2024) 327, 118008 DOI: 10.1016/j.jep.2024.118008
Cheng, Chong, Hsieh et al
J Ethnopharmacol (2024) 327, 118008 DOI: 10.1016/j.jep.2024.118008
Cited by 8
AI Summary: OriGene's collagen-1a1 antibody (TA309096) was used in this study to detect and quantify collagen expression in lung fibrosis cell models, aiding in the evaluation of the anti-fibrotic effects of Ganoderma formosanum extracts.
Snippet: were blocked with 5% skim milk in TBS-Tween 0.1% buffer and then incubated with primary antibodies overnight, including collagen-1a1 (1:1000, OriGene, MD, USA, TA309096), fibronectin (1:1000, BD Biosciences, CA, USA, 610077), elastin (1:1000, Proteintech, 15257-1-AP), α-SMA (1:1000, Abcam, Cambridge, UK, ab5694), β-actin (1:5000, Cell Signaling, 13E5 #4970), and Caspase-3 (1:1000, Cell Signaling, #9662). …
Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis
Yu, Yeh, Ye et al
J Med Chem (2023) 66 (15), 10528-10557 DOI: 10.1021/acs.jmedchem.3c00644
Yu, Yeh, Ye et al
J Med Chem (2023) 66 (15), 10528-10557 DOI: 10.1021/acs.jmedchem.3c00644
Cited by 27
AI Summary: In this study, the OriGene collagen-1a1 antibody (TA309096) was used to detect collagen-1a1 protein levels, aiding in the evaluation of fibrosis markers during the screening of novel HDAC inhibitors for idiopathic pulmonary fibrosis treatment.
Snippet: … Pan-histone deacetylase inhibitors such as Save;Membranes were incubated overnight at 4 °C with primary antibodies against collagen-1a1 (1:1000, OriGene, MD, USA, TA309096, for human species), fibronectin (1:1000, BD Biosciences, CA, USA, 610077), elastin (1:1000, Proteintech, 15257-1-AP), α-SMA (1:1000, Abcam, Cambridge, UK, ab5694), β-actin (1:5000, Cell Signaling, 13E5 #4970), acetyl-SMC3 (1:1000, kindly provided by Prof. …
Characterization and anti-aging effects of Opuntia ficus-indica (L.) Miller extracts in a D-galactose-induced skin aging model
Abbas, Ezzat, Ramadan et al
Food Funct (2023) 14 (7), 3107-3125 DOI: 10.1039/d2fo03834j
Abbas, Ezzat, Ramadan et al
Food Funct (2023) 14 (7), 3107-3125 DOI: 10.1039/d2fo03834j
Cited by 21
AI Summary: OriGene's rabbit polyclonal anti-COL1A1 antibody (CAT#: TA309096) was used in this study to detect collagen I in skin tissue sections, enabling assessment of collagen restoration following treatment with Opuntia ficus-indica extracts.
Snippet: Opuntia ficus-indica (L.) Miller (OFI), belonging to the family Cactaceae, is widely cultivated not only for its delicious fruits but also for its health-promoting effects, which Save;Skin sections were rehydrated, blocked in 5% normal goat serum, and incubated with the primary anti-collagen I antibody (rabbit polyclonal anti-COL1A1 1[thin space (1/6-em)]:[thin space (1/6-em)]100;CAT#: TA309096;Origene, USA) overnight at 4 °C
Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts
Chen, Jhao, Hung et al
J Clin Invest (2021) 131 (5) DOI: 10.1172/JCI143645
Chen, Jhao, Hung et al
J Clin Invest (2021) 131 (5) DOI: 10.1172/JCI143645
AI Summary: In this study, OriGene products—including COL1A1 (TA309096), TGFBR2 (TA323092), and TGFBR1 (TA311643) antibodies—were used to detect key proteins involved in kidney fibroblast activation and TGF-β signaling, supporting the investigation of TXNDC5’s role in promoting renal fibrosis.
Snippet: … Endoplasmic Reticulum Protein TXNDC5 Promotes Renal Fibrosis by Enforcing TGFβ Signaling in Kidney Fibroblasts Yen-Ting Chen,1 Pei-Yu Jhao,1 Chen-Ting Hung,1 Yueh-Feng Wu,2,3 Sung-Jan Lin,2,3,4 Wen-Chih;COL1A1 (1:1000, Aviva Systems Biology, CA, USA, OAAB10798, for mouse species), COL1A1 (1:1000, OriGene, MD, USA, TA309096, for human species), CCN2, TGFBR2 (1:1000, OriGene, MD, USA, TA323092, TA311643),
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
Lee, Yeh, Lee et al
Nat Commun (2020) 11 (1), 4254 DOI: 10.1038/s41467-020-18047-x
Lee, Yeh, Lee et al
Nat Commun (2020) 11 (1), 4254 DOI: 10.1038/s41467-020-18047-x
Cited by 134
AI Summary: In this study, OriGene products including TXNDC5 shRNA (OriGene, TL504964) and TXNDC5 cDNA (OriGene, MR205969) were used to modulate TXNDC5 expression in lung fibroblasts, enabling the authors to investigate TXNDC5’s role in promoting pulmonary fibrosis via TGFβ signaling.
Human chondrocyte-conditioned medium promotes chondrogenesis of bone marrow stem cells
Razali, Lokanathan, Chowdhury et al
Asian Biomedicine (2020) 14 (1), 9-18 DOI: 10.1515/abm-2020-0003
Razali, Lokanathan, Chowdhury et al
Asian Biomedicine (2020) 14 (1), 9-18 DOI: 10.1515/abm-2020-0003
Cited by 2
Snippet: n with 0.5% Triton X-100 solution (Sigma-Aldrich), and blocked with 10% goat serum (Sigma-Aldrich) for 1 h at 37°C. The cells were subsequently incubated with 1:200 rabbit anti-collagen 1 (TA309096;OriGene, USA) and 1:200 mouse anti-collagen II antibodies (ab185430;Abcam, USA) overnight at 4°C. On the following day, the cells were washed before being incubated with Alexa Fluor 594 goat anti-ra
Showing 1-6 of 15 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
