UNC13B Rabbit Polyclonal Antibody

SKU TA308991

Rabbit Polyclonal antibody to UNC13B (unc-13 homolog B (C. elegans))

Product Data

• Application: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:1000-1:10000
• Reactivity: Bovine), Human (Predicted: Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 462 and 749 of UNC13B (Uniprot ID#O14795)
• Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 181 kDa
• Gene Name: unc-13 homolog B (C. elegans)
• Database Link:
  NP_006368
  O14795
• Background: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq]
• Synonyms: MUNC13; UNC13; Unc13h2
• Note: Seq homology of immunogen across species: Mouse (98%), Rat (98%), Bovine (97%)

Reference Data

• Protein Families: Druggable Genome