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UNC13B Rabbit Polyclonal Antibody

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SKU
TA308991
Rabbit Polyclonal antibody to UNC13B (unc-13 homolog B (C. elegans))
Size:
100 ul
Conjugation:
Unconjugated
  $665.00
5 Days*
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Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution IHC:1:100-1:1000; WB:1:1000-1:10000
Reactivity Bovine), Human (Predicted: Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant fragment corresponding to a region within amino acids 462 and 749 of UNC13B (Uniprot ID#O14795)
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 181 kDa
Gene Name unc-13 homolog B (C. elegans)
Database Link
Background This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. provided by RefSeq
Synonyms MUNC13; UNC13; Unc13h2
Note Seq homology of immunogen across species: Mouse (98%), Rat (98%), Bovine (97%)
Reference Data
Protein Categories Intracellular Proteins
Protein Families Druggable Genome
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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