Endothelin 3 (EDN3) Rabbit Polyclonal Antibody

CAT#: TA308462

Rabbit polyclonal antibody to Endothelin 3 (endothelin 3)

Product Images

Sample (30 ug of whole cell lysate). A: Raji. 12% SDS PAGE. TA308462 diluted at 1:1000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 217 of ET-3 (Uniprot ID#P14138)
• Formulation: 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 25 kDa
• Gene Name: endothelin 3
• Database Link:
  NP_996916
  Entrez Gene 1908 Human
  UniProt ID P14138
• Background: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq]
• Synonyms: ET-3; ET3; HSCR4; PPET3; WS4B

Reference Data

• Protein Families: Druggable Genome, Secreted Protein