DPYD Rabbit Polyclonal Antibody

CAT#: TA308200

Rabbit polyclonal antibody to DPYD (dihydropyrimidine dehydrogenase)

Product Images

Sample (30 ug of whole cell lysate). A: Raji. B: K562. C: NCI-H929. 7.5% SDS PAGE. TA308200 diluted at 1:1000.

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  DPYD antibody [N1N2], N-term detects DPYD protein at cytoplasm on H358 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded H358 xenograft. DPYD antibody [N1N2], N-term (TA308200) dilution: 1:500.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 174 of (Uniprot ID#Q12882)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 19 kDa
• Gene Name: dihydropyrimidine dehydrogenase
• Database Link:
  NP_000101
  Entrez Gene 1806 Human
  UniProt ID Q12882
• Background: The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. [provided by RefSeq]
• Synonyms: DHP; DHPDHASE; DPD

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: beta-Alanine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Pantothenate and CoA biosynthesis, Pyrimidine metabolism