RHBDD3 Rabbit Polyclonal Antibody

CAT#: TA306892

Rabbit Polyclonal RHBDD3 Antibody

Product Images

Western blot analysis of RHBDD3 in rat lung tissue lysate with RHBDD3 antibody at 1 ug/ml.

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  Immunofluorescence of RHBDD32 in rat lung tissue with RHBDD3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RHBDD3 antibody was raised against a 13 amino acid peptide from near the center of human RHBDD3 .
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: rhomboid domain containing 3
• Database Link:
  NP_036397
  Entrez Gene 279766 MouseEntrez Gene 289753 RatEntrez Gene 25807 Human
  UniProt ID Q9Y3P4
• Background: The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD3 was initially identified as a novel pituitary tumor apoptosis gene (PTAG) whose expression was reduced in certain pituitary adenomas. Overexpression of RHBDD3 in AtT20 cells showed an increase in apoptotic activity and caspase activation in response to bromocriptine, and apoptosis-inducing dopamine D2 analog, suggesting that reactivation of RHBDD3 in tumors may be a therapeutically useful tool. Later experiments also showed that RHBDD3 expression is also reduced in several primary colorectal tumors, indicating that loss of RHBDD3 contributes to a blunted apoptotic response and probably predisposes cells towards malignant transformation.
• Synonyms: C22orf3; HS984G1A; PTAG

Reference Data

• Protein Families: Druggable Genome, Transmembrane