SIPA1L3 Rabbit Polyclonal Antibody

SKU
TA306878
Rabbit Polyclonal SIPA1L3 Antibody
  $640.00
5 Days*
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Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen SIPA1L3 antibody was raised against a 15 amino acid peptide from near the amino terminus of human SIPA1L3.
Buffer PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name signal induced proliferation associated 1 like 3
Database Link
Background Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice (3) and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.
Synonyms SPAL3
Reference Data
Protein Categories Intracellular Proteins, Nervous system Diseases
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