ORAI2 Rabbit Polyclonal Antibody

CAT#: TA306419

Rabbit Polyclonal ORAI2 Antibody

Product Images

Western blot analysis of ORAI2 in Jurkat cell lysate with ORAI2 antibody at (A) 1, (B) 2 and (C) 4 ug/mL.

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  Immunocytochemistry of ORAI2 in Jurkat cells with ORAI2 antibody at 5 ug/mL.

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  Immunofluorescence of ORAI2 in Jurkat cells with ORAI2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 4 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ORAI2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human ORAI2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ORAI calcium release-activated calcium modulator 2
• Database Link:
  NP_001119812
  Entrez Gene 269717 MouseEntrez Gene 80228 Human
  UniProt ID Q96SN7
• Background: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor, although at a lesser efficacy than ORAI1. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI3.
• Synonyms: C7orf19; CBCIP2; MEM142B; TMEM142B

Reference Data

• Protein Families: Transmembrane