TWEAK (TNFSF12) Rabbit Polyclonal Antibody

CAT#: TA306313

Rabbit Polyclonal TWEAK Antibody

Product Images

Western blot analysis of TWEAK in HeLa cell lysate with TWEAK antibody at (A) 1 and (B) 2ug/ml.

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  Immunohistochemistry of TWEAK in mouse brain tissue with TWEAK antibody at 5ug/ml.

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  Immunohistochemistry of TWEAK in human brain tissue with TWEAK antibody at 10ug/ml.

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  Immunofluorescence of TWEAK in mouse brain tissue with TWEAK antibody at 20ug/ml.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TWEAK antibody was raised against recombinant human TWEAK protein.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Purified IgG
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor superfamily member 12
• Database Link:
  NP_003800
  Entrez Gene 21944 MouseEntrez Gene 360548 RatEntrez Gene 8742 Human
  UniProt ID O43508
• Background: TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane (1,2). TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis (3), induction of inflammatory cytokines (4), in addition to stimulation of apoptosis (5). The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains (1). Despite its predicted molecular weight of 27kDa, TWEAK may migrate at aberrant positions in SDS-PAGE.
• Synonyms: APO3L; DR3LG; TWEAK

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction