PIST (GOPC) Rabbit Polyclonal Antibody

SKU TA306264

Rabbit Polyclonal PIST Antibody

Product Data

• Application: IF, IHC, WB
• Recommended Dilution: WB: 1 - 4 ug/mL, ICC: 1 ug/mL, IF: 20 ug/mL
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PIST antibody was raised against a 17 amino acid peptide from near the center of human PIST.
• Buffer: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: golgi-associated PDZ and coiled-coil motif containing
• Database Link:
  AAG00572
  Q9HD26
• Background: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). PIST, a PDZ-containing protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (4-6). Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1 (6).
• Synonyms: CAL; dJ94G16.2; FIG; GOPC1; PIST

Reference Data