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SARM (SARM1) Rabbit Polyclonal Antibody

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SKU
TA306162
Rabbit Polyclonal SARM Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
2 Weeks*
Bulk/Customize

Frequently Bought Together (2)

TA811000S beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control 30 ul
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TP315903 Recombinant protein of human sterile alpha and TIR motif containing 1 (SARM1), 20 µg
20 ug
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View other "SARM or NM_015077" antibodies

Specifications
Specifications
Product Data
Application IF, WB
Recommended Dilution WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 2 ug/mL
Reactivity Human, Mouse
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen SARM antibody was raised against a peptide corresponding to amino acids near the C-terminus of human SARM.
Buffer PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification Ion exchange chromatography purified
Conjugation Unconjugated
Storage Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name sterile alpha and TIR motif containing 1
Database Link
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kappaB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.
Synonyms MyD88-5; SAMD2; SARM
Reference Data
Protein Categories Intracellular Proteins
Protein Families Druggable Genome
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Documents
Resources

file-alt Citations

Activation of TLR3 Promotes the Degeneration of Retinal Ganglion Cells by Upregulating the Protein Levels of JNK3
Chintala, Putris, Geno
Invest. Ophthalmol. Vis. Sci. (2015) 56 (1), 505-14 DOI: 10.1167/iovs.14-15539
Cited by 23
AI Summary: OriGene's SARM1 antibody was used for Western blot analysis to detect SARM1 protein levels in retinal extracts, contributing to the investigation of molecular changes during retinal ganglion cell degeneration in the study.
Snippet: WI, USA), respectively. SARM1 antibodies were obtained either from Origene (Rockville, MD, USA;for Western blot analysis) or from GenWay Biotech, Inc. (San Diego, CA, USA;for immunohistochemistry). Antibodies against ... Related articles All 4 versions Cite SaveSaving
WB IHC
Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons
Massoll, Mando, Chintala
Invest. Ophthalmol. Vis. Sci. (2013) 54 (4), 2771-80 DOI: 10.1167/iovs.12-10973
Cited by 39
AI Summary: In this study, OriGene's primary antibodies against SARM1 were used for Western blot analysis to measure SARM1 protein levels in retinal tissue following excitotoxic injury.
Snippet: Louis, MO). For Western blot analysis of SARM1, primary antibodies were obtained from Origene (Rockville, MD). ... Sarm1 silencer predesigned siRNA (cat# AM16708) and silencer negative control siRNA (cat# AM4611) were obtained from Life Technologies (Grand Island, NY).
WB IHC
Showing 1-2 of 2 papers.
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