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CACNA1C Goat Polyclonal Antibody

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SKU
TA305878
Goat Anti-CACNA1C Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $565.00
In Stock*
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View other "CACNA1C or NM_000719" antibodies

Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB: 0.5-1.5ug/ml.
Reactivity Human
Antibody Host Goat
Isotype IgG
Clonality Polyclonal
Immunogen Peptide with sequence C-RARGRPSEEELQD, from the C Terminus of the protein sequence according to NP_000710.5.
Buffer 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name calcium voltage-gated channel subunit alpha1 C
Database Link
Background This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. provided by RefSeq
Synonyms CACH2; CACN2; CACNL1A1; CaV1.2; CCHL1A1; LQT8; TS
Reference Data
Protein Categories Cardiovascular diseases, Membrane Proteins
Protein Families Druggable Genome, Ion Channels: Calcium, Transmembrane
Protein Pathways Alzheimer's disease, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Calcium signaling pathway, Cardiac muscle contraction, Dilated cardiomyopathy, GnRH signaling pathway, Hypertrophic cardiomyopathy (HCM), Long-term potentiation, MAPK signaling pathway, Type II diabetes mellitus, Vascular smooth muscle contraction
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Documents
Resources

file-alt Citations

Vitis labrusca extract effects on cellular dynamics and redox modulations in a SH-SY5Y neuronal cell model: a similar role to lithium
Scola, Laliberte, Kim et al
Neurochem Int (2014) 79, 12-9 DOI: 10.1016/j.neuint.2014.10.002
Cited by 14
AI Summary: In this paper, OriGene's Anti-CACNA1C antibody (TA322879) was used to assess the relative levels of the CACNA1c calcium channel in SH-SY5Y cells, enabling the evaluation of Vitis labrusca extract's neuroprotective effects compared to lithium.
Vitis labrusca extract effects on cellular dynamics and redox modulations in a SH-SY5Y neuronal cell model: A similar role to lithium
Scola, Laliberte, Kim et al
Neurochemistry International (2014)
AI Summary: OriGene's Goat Anti-CACNA1c Antibody (TA305878) was used in this study to detect CACNA1c protein expression in SH-SY5Y neuronal cells, contributing to the analysis of Vitis labrusca extract effects on cellular dynamics.
Snippet: Cells were blocked with 1% BSA for 1 hour and washed 2 times in DPBS. Cells were incubated with primary antibody for 16 hours at 4°C diluted in DPBS-0.4% Triton-X: Goat Anti-CACNA1c Antibody (Origene, US;TA305878;1:100). ... Cite SaveSaving
ICC
Showing 1-2 of 2 papers.
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