TIA1 Goat Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | ELISA: 1:128,000. WB: 0.1-0.3µg/ml.IHC:3.75µg/ml.IF:5µg/ml. |
| Reactivity | Dog), Human (Expected from sequence similarity: Mouse, Rat |
| Antibody Host | Goat |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Peptide with sequence C-PKSTYESNTKQ, from the internal region of the protein sequence according to NP_071320.1; NP_071505.1. |
| Buffer | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Concentration | lot specific |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | TIA1 cytotoxic granule-associated RNA binding protein |
| Database Link | |
| Background | The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. provided by RefSeq |
| Synonyms | TIA-1; WDM |
| Reference Data | |
| Protein Categories | Cytokines, Intracellular Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Druggable Genome |
Reviews
Documents
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Citations
Dual mechanism for the translation of subgenomic mRNA from Sindbis virus in infected and uninfected cells
Sanz, Castelló, Ventoso et al
PLoS One (2009) 4 (3), e4772 DOI: 10.1371/journal.pone.0004772
Sanz, Castelló, Ventoso et al
PLoS One (2009) 4 (3), e4772 DOI: 10.1371/journal.pone.0004772
Cited by 50
AI Summary: In this study, OriGene’s anti-eIF2α antibody (TA500819) and anti-eIF4G antibody (TA811061) were used for immunolocalization experiments to analyze the cellular distribution of translation initiation factors in Sindbis virus-infected cells, helping to elucidate mechanisms of viral mRNA translation.
Showing 1-1 of 1 papers.
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