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KPNA2 Goat Polyclonal Antibody

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SKU
TA302917
Goat Polyclonal Antibody against KPNA2
Size:
100 ug
Conjugation:
Unconjugated
  $565.00
5 Days*
Bulk/Customize

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View other "KPNA2 or NM_002266" antibodies

Specifications
Specifications
Product Data
Application FC, IF, IHC, PEP-ELISA, WB
Recommended Dilution WB: 1-3 µg/ml
Reactivity Dog), Human (Expected from sequence similarity: Mouse, Rat
Antibody Host Goat
Isotype IgG
Clonality Polyclonal
Immunogen Peptide with sequence C-QVQDGAPGTFNF, from the C Terminus of the protein sequence according to NP_002257.1.
Buffer Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration lot specific
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name karyopherin subunit alpha 2
Database Link
Background The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination provided by RefSeq.
Synonyms IPOA1; QIP2; RCH1; SRP1-alpha; SRP1alpha
Reference Data
Protein Categories Intracellular Proteins
Protein Families Druggable Genome, Stem cell - Pluripotency
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Documents
Resources

file-alt Citations

Normal male fertility in a mouse model of KPNA2 deficiency
Rother, Hweidi, Hartmann et al
bioRxiv (2024)
Snippet: The sections were then treated with 10% normal donkey serum for 1h at room temperature and subsequently incubated with KPNA2 antibody (Origene TA302917 1:100)
IHC
Showing 1-1 of 1 papers.
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