5HT3A receptor (HTR3A) Goat Polyclonal Antibody
$565.00
5 Days*
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | ELISA: 1:128,000. WB: 0.3-1µg/ml. |
| Reactivity | Human, Rat |
| Antibody Host | Goat |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Peptide with sequence C-GPQDFEKSPRDR, from the internal region of the protein sequence according to NP_998786.1; NP_000860.1. |
| Buffer | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Concentration | lot specific |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 62016 Da |
| Gene Name | 5-hydroxytryptamine receptor 3A |
| Database Link | |
| Background | The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. provided by RefSeq |
| Synonyms | 5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3 |
| Reference Data | |
| Protein Categories | Membrane Proteins |
| Protein Families | Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Diffuse noxious inhibitory controls in chronic joint inflammatory Pain: Study of the descending serotonergic modulation mediated through 5HT3 receptors
Pereira-Silva, Serrão, Lourença Neto et al
Neurobiology of Pain (2023) 13, 100123 DOI: 10.1016/j.ynpai.2023.100123
Pereira-Silva, Serrão, Lourença Neto et al
Neurobiology of Pain (2023) 13, 100123 DOI: 10.1016/j.ynpai.2023.100123
Cited by 5
Snippet: ns was performed in 30 µm spinal L4 and L5 segments, as we described (Costa-Pereira et al., 2020). A polyclonal goat anti-5-HT3AR primary antibody (1:400, 2 overnights at 4 °C;Cat. No. TA302602;Origene, Miami, Florida, USA) was detected with a horse anti-goat biotinylated secondary antibody (Cat. No. BA-9500;Vector, Burlingame, California, USA) and with an Alexa Streptavidin 488 (Cat. No. S
Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy-induced neuropathy: The role of spinal 5-HT3 receptors
Costa-Pereira, Serrão, Martins et al
Eur J Neurosci (2020) 51 (8), 1756-1769 DOI: 10.1111/ejn.14614
Costa-Pereira, Serrão, Martins et al
Eur J Neurosci (2020) 51 (8), 1756-1769 DOI: 10.1111/ejn.14614
Cited by 42
AI Summary: In this paper, OriGene's anti-TPH antibody (TPH, TA500690) was used for double immunohistochemistry to identify and quantify serotoninergic neurons in the rostral ventromedial medulla (RVM), helping demonstrate increased activation of these neurons in chemotherapy-induced neuropathy.
Showing 1-2 of 2 papers.
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