KPNA3 Goat Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | ELISA: 1/32,000. WB: 0.1-0.5µg/ml. IHC: 5-10µg/ml. |
| Reactivity | Cow), Human, Mouse, Rat (Expected from sequence similarity: Dog |
| Antibody Host | Goat |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Peptide with sequence C-DPTANLQTKEFNF, from the C Terminus of the protein sequence according to NP_002258. |
| Buffer | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Concentration | lot specific |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 61439 Da |
| Gene Name | karyopherin subunit alpha 3 |
| Database Link | |
| Background | The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. provided by RefSeq |
| Synonyms | hSRP1; IPOA4; SRP1; SRP1gamma; SRP4 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Nervous system Diseases |
Reviews
Documents
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Citations
HE4 expression is associated with hormonal elements and mediated by importin-dependent nuclear translocation
Lokich, Singh, Han et al
Sci Rep (2014) 4, 5500 DOI: 10.1038/srep05500
Lokich, Singh, Han et al
Sci Rep (2014) 4, 5500 DOI: 10.1038/srep05500
Cited by 52
AI Summary: OriGene products contributed to this study by providing the HE4 overexpression plasmid (RC204307) and HE4 shRNA (TL313573), which were used to manipulate HE4 expression levels and investigate its role in hormone response and nuclear translocation in ovarian cancer cells.
Snippet: Human epididymis protein 4 (HE4) is overexpressed in EOC and appears to have a role in ovarian cancer tumorigenesis. Little is known about the biologic function of the WFCD2 gene or its gene product HE4. However, there are hormonal responsive elements present within the WFCD2 promoter and we therefore hypothesized that steroid hormones could influence expression of HE4 in ovarian cancer
Showing 1-1 of 1 papers.
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