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Biglycan (BGN) Goat Polyclonal Antibody

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SKU
TA302434
Goat Polyclonal Antibody against Biglycan Preproprotein
Size:
100 ug
Conjugation:
Unconjugated
  $565.00
5 Days*
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Frequently Bought Together (2)

TA811000S beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control 30 ul
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LY400642 Transient overexpression lysate of biglycan (BGN) (as WB positive control) 100 ug
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View other "Biglycan or NM_001711" antibodies

Specifications
Specifications
Product Data
Application WB
Recommended Dilution ELISA: 1:8,000. WB: 0.1-0.3µg/ml.
Reactivity Dog), Human, Rat (Expected from sequence similarity: Mouse
Antibody Host Goat
Isotype IgG
Clonality Polyclonal
Immunogen Peptide with sequence C-DRLAIQFGNYKK, from the C Terminus of the protein sequence according to NP_001702.1.
Buffer Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration lot specific
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 45280 Da
Gene Name biglycan
Database Link
Background The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival. This gene is a candidate gene for the Happle syndrome. provided by RefSeq
Synonyms DSPG1; PG-S1; PGI; SLRR1A
Reference Data
Protein Categories Secreated Proteins
Protein Families Secreted Protein
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Documents
Resources

file-alt Citations

Biglycan is a new high-affinity ligand for CD14 in macrophages
Roedig, Nastase, Frey et al
Matrix Biol. (2019) 77, 4-22 DOI: 10.1016/j.matbio.2018.05.006
AI Summary: In this study, OriGene’s human biglycan expression plasmid (RC217445) and CD14 expression plasmid (RC216307) were used to transiently overexpress biglycan and CD14, respectively, in cell and animal models to investigate their roles in macrophage-mediated inflammatory signaling.
Snippet: The following primary antibodies were used: goat anti-human biglycan (TA302434, Acris Antibodies, Germany), mouse anti-β‑actin (A5441, Sigma Aldrich, Germany), mouse anti-CD14 (ab182032, Abcam, Germany), rabbit anti-Hsp70 antibody (ab181606, Abcam, Germany), rabbit anti-phospho-p38 (#9211, Cell Signaling, Germany), rabbit anti-total p38 (#9212, Cell Signaling, Germany), rabbit anti-phospho-p44/42 (#9101, Cell Signaling, Germany), rabbit anti-total p44/42 (#9102, Cell signaling, Germany), rabbit anti-phospho-NF-κB p65 (Ser536) (93H1) (#3033, Cell Signaling, Germany) and rabbit anti-NF-κB p65
WB
A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia
Frey, Moreth, Hsieh et al
Glycoconj J (2017) 34 (3), 393-404 DOI: 10.1007/s10719-016-9722-y
Cited by 21
AI Summary: OriGene products contributed to this study by providing the mouse HIF-2α (EPAS1) cDNA clone (OriGene, MC210073) and Epo (Erythropoietin) cDNA clone (OriGene, MC200527), which were used for gene expression and functional analyses of HIF-2α and Epo in the investigation of biglycan's role in polycythemia.
Showing 1-2 of 2 papers.
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