Cadherin 8 (CDH8) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB:1/1000, IHC-P:1/50-200 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | This CDH8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-63 amino acids from the N-terminal region of human CDH8. |
| Specificity | This CDH8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-63 amino acids from the N-terminal region of human CDH8. |
| Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Concentration | lot specific |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 88.3 kDa |
| Gene Name | cadherin 8 |
| Database Link | |
| Background | CDH8 is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. |
| Synonyms | Nbla04261 |
| Reference Data | |
| Protein Families | Transmembrane |
Reviews
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Citations
Ectopic expression of cadherin 8 is sufficient to cause cyst formation in a novel 3D collagen matrix renal tubule culture
Kher, Sha, Escobar et al
Am. J. Physiol., Cell Physiol. (2011) 301 (1), C99-C105 DOI: 10.1152/ajpcell.00151.2010
Kher, Sha, Escobar et al
Am. J. Physiol., Cell Physiol. (2011) 301 (1), C99-C105 DOI: 10.1152/ajpcell.00151.2010
Cited by 14
AI Summary: OriGene products contributed to this study by providing anti-cadherin 8 and monoclonal anti-Flag antibodies, which were used to detect cadherin 8 expression and Flag-tagged proteins in renal epithelial cells.
Snippet: Anti-cadherin 8 was supplied by Santa Cruz Biotechnology (Santa Cruz, CA) and OriGene Technologies (Rockville, MD). ... Samples were labeled with monoclonal anti-Flag (OriGene), Texas Red-conjugated phalloidin (Invitrogen), and Hoescht 33342 (Invitrogen).
Showing 1-1 of 1 papers.
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