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Endothelin B Receptor (EDNRB) (N-term, Extracel. Dom.) Rabbit Polyclonal Antibody

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SKU
SP4124P
Endothelin B Receptor (EDNRB) (N-term, Extracel. Dom.) rabbit polyclonal antibody, Aff - Purified
Size:
50 ug
Conjugation:
Unconjugated
  $550.00
3 Weeks*
Bulk/Customize

View other "EDNRB or NP_000106.1" antibodies

Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution Immunocytochemistry.
Immunohistochemistry on Paraffin Sections: 4 - 11 µg/ml.
Western Blot.
Reactivity Canine, Human
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Synthetic 19 amino acid peptide from N-terminal extracellular domain of human EDNRB
Specificity Detects N-terminal extracellular domain of Endothelin B Receptor (Family: GPCR; Subfamily: Endothelin).
Buffer PBS containing 0.09% Sodium Azide as preservative
State: Aff - Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Peptide Immunogen Affinity Chromatography
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20 to -70°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name endothelin receptor type B
Database Link
Background The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct.
The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel.
Synonyms ET-BR, ET-B, EDNRB, ETRB, ETB, ETBR, HSCR, WS4A, ABCDS, HSCR2
Reference Data
Protein Categories ADC Targets, Cancer: Head and Neck, GPCR, Membrane Proteins
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Documents
Resources

file-alt Citations

Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma
Tanaka, Sho, Takayama et al
Br J Cancer (2014) 110 (4), 1027-33 DOI: 10.1038/bjc.2013.784
Cited by 27
AI Summary: OriGene products, specifically anti-ETBR (Endothelin Receptor Type B) antibody and CD31 antibody, were used for immunohistochemical analysis to evaluate ETBR expression and microvessel density in oesophageal squamous cell carcinoma tissues, contributing to the study’s findings on the correlation between ETBR expression, tumour angiogenesis, and patient prognosis.
FigureFigureFigure
Showing 1-1 of 1 papers.
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