Endothelin B Receptor (EDNRB) (N-term, Extracel. Dom.) Rabbit Polyclonal Antibody

CAT#: SP4124P

Endothelin B Receptor (EDNRB) (N-term, Extracel. Dom.) rabbit polyclonal antibody, Aff - Purified

Product Images

Figure 1. Immunohistochemical staining of Adrenal (Medulla) using anti-Endothelin B Receptor antibody.

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  Figure 2. Cells expressing target protein-immunostained with target antibody.

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  Figure 3. Cells expressing vector only - immunostained with target antibody

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunocytochemistry.
  Immunohistochemistry on Paraffin Sections: 4 - 11 µg/ml.
  Western Blot.
• Reactivities: Canine, Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic 19 amino acid peptide from N-terminal extracellular domain of human EDNRB
• Specificity: Detects N-terminal extracellular domain of Endothelin B Receptor (Family: GPCR; Subfamily: Endothelin).
• Formulation: PBS containing 0.09% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Peptide Immunogen Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20 to -70°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: endothelin receptor type B
• Database Link:
  Entrez Gene 1910 Human
  UniProt ID P24530
• Background: The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct.
  The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel.
• Synonyms: ET-BR, ET-B, EDNRB, ETRB, ETB, ETBR, HSCR, WS4A, ABCDS, HSCR2