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NTAL (LAT2) Mouse Monoclonal Antibody [Clone ID: NAP-03]

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SKU
SM3123P
NTAL (LAT2) mouse monoclonal antibody, clone NAP-03, Purified
Size:
100 ug
Conjugation:
Unconjugated
  $385.00
2 Weeks*
Bulk/Customize

View other "LAT2 or NP_054865.2" antibodies

Specifications
Specifications
Product Data
Clone Name NAP-03
Application IHC, IP, WB
Recommended Dilution Immunoprecipitation.
Western Blot: Recommended dilution: 1-2 mg/ml, incubation 60 min.
Positive control: RAMOS human lymphoma cell line.
Sample preparation: Resuspend approx. 50 mil. cells in 1 ml cold Lysis buffer (1% laurylmaltoside in 20 mM Tris/Cl, 100 mM NaCl pH 8.2, 50 mM NaF including Protease inhibitor Cocktail). Incubate 60 min on ice. Centrifuge to remove cell debris. Mix lysate with non-reducing SDS-PAGE sample buffer.
Application note: Non-Reducing conditions. 12% separating SDS-PAGE gel.
Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/ml, Positive tissue: tonsil, germinal center.
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Peptide corresponding to aa 196-212 of human NTAL coupled to KLH
Specificity The antibody recognizes the defined epitope (aa 196-212) of Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
State: Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Protein A affinity chromatography; > 95 % (by SDS-PAGE)
Conjugation Unconjugated
Storage Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name linker for activation of T-cells family member 2
Database Link
Background NTAL (Non-T cell Activation Linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells.
However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Synonyms LAB, NTAL, WBS15, WBSCR5, HSPC046
Reference Data
Protein Categories Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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