CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: MEM-06]

CAT#: SM3021R

CD41 (ITGA2B) mouse monoclonal antibody, clone MEM-06, PE

Product Images

Surface staining of human platelets with anti-human CD41 (MEM-06) PE.

Specifications

Product Data

• Clone Name: MEM-06
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of human blood cells using 20 µl reagent/100 µl of whole blood or 10⁶ cells in a suspension.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Leukocytes of patient suffering from LGL-type leukaemia
• Specificity: This antibody reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIbalpha (heavy chain: 120 kDa) and GPIIbbeta (light chain: 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
• Formulation: Phosphate buffered saline (PBS) containing 15 mM Sodium Azide as preservative
  Label: PE
  State: Liquid purified Ig fraction
  Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
• Conjugation: PE
• Storage: Store the antibody at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin subunit alpha 2b
• Database Link:
  Entrez Gene 3674 Human
  UniProt ID P08514
• Background: CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, a and 23 kDa b, b) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
• Synonyms: Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb