CD321 / JAM1 Rat Monoclonal Antibody [Clone ID: H202-106]
Specifications
| Product Data | |
| Clone Name | H202-106 |
|---|---|
| Application | FC, IHC, IP |
| Recommended Dilution | Immunoprecipitation. Immunohistochemistry on Frozen Sections. Flow Cytometry: Use 10 µl of 1/100-1/200 diluted antibody to label 10e6 cells in 100 ul. |
| Reactivity | Mouse |
| Antibody Host | Rat |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | MTE1/MTE2 stromal cell lines. |
| Specificity | Recognises murine CD321, which is also known as junctional adhesion molecule 1 (JAM-1). |
| Buffer | PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction. |
| Concentration | lot specific |
| Purification | Affinity Chromatography on Protein G. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | F11 receptor |
| Database Link | |
| Background | CD321 is a 32-41kD glycoprotein, which shares similarities with related proteins JAM-2 and JAM-3. It is a multifunctional protein that is primarily expressed by platelets, endothelial and epithelial cells. The CD321 protein co-localises with tight junction molecules in both epithelial and endothelial cells and plays an important role in the regulation of junctional integrity and permeability. In addition, CD321 is a ligand for the integrin LFA-1 and is also involved in the transmigration of leucocytes. |
| Synonyms | JAM-A, Platelet F11 receptor, F11R, JCAM, PAM1 |
| Reference Data | |
| Protein Categories | CD Markers, Cytokines, Membrane Proteins |
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