Integrin alpha 4 (ITGA4) Mouse Monoclonal Antibody [Clone ID: HP2/1]
$470.00
5 Days*
Specifications
| Product Data | |
| Clone Name | HP2/1 |
|---|---|
| Application | FC, IHC, IP |
| Recommended Dilution | Flow cytometry: 1 µg/5 x 10e cells. Immunohistochemsitry on frozen sections. Immunoprecipitation. |
| Reactivity | Bovine, Human, Monkey, Porcine, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | JM leukaemia line. Spleen cells from immunised BALB/c mice were fused with cells of the X63 Ag8.653 myeloma cell line. |
| Specificity | This antibody recognises the 80kD alpha chain of VLA-4. Reacts with monocytes, T cells, B cells, thymocytes and Langerhans cells. Can be used in basic studies of VLA-4 mediated adhesion and its interaction with the VCAM-1 structure. HP2/1 inhibits cell binding to soluble VCAM-1. |
| Buffer | PBS containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction. |
| Concentration | lot specific |
| Purification | Affinity chromatography on Protein G |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | integrin subunit alpha 4 |
| Database Link | |
| Background | ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling. |
| Synonyms | Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4 |
| Reference Data | |
| Protein Categories | CD Markers, Chemokines, Cytokines, Intracellular Proteins, Membrane Proteins |
Reviews
Documents
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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