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IGF2R Mouse Monoclonal Antibody [Clone ID: MEM-238]

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SKU
SM2004F
IGF2R mouse monoclonal antibody, clone MEM-238, FITC
Size:
100 Tests
Conjugation:
FITC Unconjugated
  $385.00
2 Weeks*
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Specifications
Specifications
Product Data
Clone Name MEM-238
Application FC
Recommended Dilution Flow Cytometry: Use 20 µl reagent/ 100 µl of whole blood or 10e6 cells.
Reactivity Human, Primate
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant Vaccinia virus encoding CD222
Specificity The antibody recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
Buffer Phosphate buffered saline (PBS) solution containing 15mM sodium azide
Label: FITC
State: Liquid purified Ig fraction
Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.
Conjugation FITC
Storage Store the antibody at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name insulin like growth factor 2 receptor
Database Link
Background CD222 is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-b, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
Synonyms CI-MPR, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, M6P/IGF2 receptor, CI Man-6-P receptor, M6PR, Late Endosome Marker, M6P/IGF2R, MPR 300
Reference Data
Protein Categories Cancer: Gastrointestinal, CD Markers, Growth Factors, Intracellular Proteins, Membrane Proteins
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Documents
Resources

file-alt Citations

The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration
Leksa, Godár, Cebecauer et al
J Biol Chem (2002) 277 (43), 40575-82 DOI: 10.1074/jbc.M207979200
AI Summary: In this study, OriGene products—specifically the human CD222 (M6PR/IGF2R) cDNA clone—were used to reintroduce CD222 into knockout mouse fibroblasts, enabling the authors to investigate how CD222 regulates plasminogen activation, cell adhesion, and chemotaxis mediated by the uPA/CD87 system.
Showing 1-1 of 1 papers.
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