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HLAB (HLA-B) Mouse Monoclonal Antibody [Clone ID: BB7.1]

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SKU
SM1304F
HLAB (HLA-B) mouse monoclonal antibody, clone BB7.1, FITC
Size:
100 ug
Conjugation:
FITC Unconjugated
  $565.00
5 Days*
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View other "HLA-B or NP_005505.2" antibodies

Specifications
Specifications
Product Data
Clone Name BB7.1
Application FC
Recommended Dilution Flow Cytometry: Use 10 µl of neat-1/10 diluted antibody to label 1x106 cells in 100 µl whole blood.
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Papain solubilized HLA-B7 antigen.
Specificity This antibody recognises the Human HLA-B7 antigen and does not cross-react with HLA-B27 or other related HLA antigens.
It can be used to distinguish true HLA-B27 positives from false HLA-B27 positives (i.e. HLA-B7 positive) in the investigation of such diseases as ankylosing spondylitis and anterior uveitis.
Buffer PBS, pH 7.4
Label: FITC
State: Liquid purified IgG fraction from Tissue Culture Supernatant
Stabilizer: 1% BSA
Preservative: 0.09% Sodium Azide
Label: Fluorescein Isothiocyanate Isomer 1
Concentration lot specific
Purification Affinity Chromatography on Protein G
Conjugation FITC
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Should this product contain a precipitate we recommend micro-centrifugation before use.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name major histocompatibility complex, class I, B
Database Link
Background HLA B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa. Hundreds of HLA B alleles have been described.
The HLA B gene is part of the human HLA complex on chromosome 6 and there are a large number of variant alleles of this gene.
Synonyms HLAB, MHC class I antigen B7
Reference Data
Protein Categories Allergies and autoimmune diseases, Intracellular Proteins, Membrane Proteins
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Documents
Resources

file-alt Citations

Adenovirus expressing β2-microglobulin recovers HLA class I expression and antitumor immunity by increasing T-cell recognition
Del Campo, Carretero, Muñoz et al
Cancer Gene Ther. (2014)
Cited by 35
AI Summary: OriGene’s rabbit monoclonal antibodies against HLA-A and HLA-B were used in this study to detect and analyze the expression of HLA class I molecules on tumor cells, contributing to the assessment of how β2-microglobulin gene transfer restores HLA class I surface expression and antitumor immunity.
Snippet: heavy chain). Antibodies to free HLA-A and HLA-B (rabbit mAbs against HLA-A and HLA-B (OriGene, Rockville, MD, USA). Rabbit polyclonal anti-human β2m (Abcam, Cambridge, UK) was used in some assays. APM components ... Cite SaveSaving
Showing 1-1 of 1 papers.
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