Pleiotrophin (PTN) Rabbit Polyclonal Antibody
$510.00
2 Weeks*
Specifications
| Product Data | |
| Application | ELISA, IHC, WB |
|---|---|
| Recommended Dilution | ELISA. Western blot. Immunohistochemistry. |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Recombinant human OSF-1 (E.coli) |
| Specificity | This antibody recognizes Human Osteoblast Specific Factor 1. |
| Buffer | Azide Free, 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2 State: Aff - Purified State: Lyophilized purified IgG fraction Preservative: None |
| Reconstitution Method | Add 0.05 ml of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation. |
| Concentration | 1.0 mg/ml (after reconstitution) |
| Purification | Immunoaffinity chromatography on a column with immobilized recombinant Human OSF-1 |
| Conjugation | Unconjugated |
| Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Gene Name | pleiotrophin |
| Database Link | |
| Background | Pleiotrophin (Osteoblast-Specific Factor-1, OSF-1) contains 136 amino acid residues. The sequence is very rich in cationic amino acids (24% of the residues); lysine cluster sequences are found in the N-terminal and Cterminal ends of the structure. The OSF-1 gene was shown by Northern blotting analysis to be expressed in mouse calvarial osteoblastenriched cells and in mouse brain tissues, but not in thymus, spleen, kidney, liver, lung, testis or heart. Pliotrophin has the ability to promote adhesion, migration, expansion, and differentiation of human osteoprogenitor cells. In addition to certain types of cancer, the embryonic growth and differentiation factor pleiotrophin is found also in adults in inflammatory diseases. In osteoarthritis, pleiotrophin is especially expressed in early stages, and its concentrations in the synovial fluid could serve as a marker for the progress of the disease. Pleitrophin might be involved in cartilage repair in osteoarthritis, in particular, in earlier stages. Total 152 AA. MW: 17.3 kDa. N-Terminal His-tag and thrombin cleavage site 16 AA (highlighted). |
| Synonyms | HBNF1, HBNF-1, NEGF1, HBBM, HBGF-8, HB-GAM, OSF1, OSF-1 |
| Reference Data | |
| Protein Categories | Growth Factors, Secreated Proteins |
Reviews
Documents
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Citations
Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium
Asari, Kanemitsu, Kurihara
J Biol Chem (2010) 285 (32), 24751-8 DOI: 10.1074/jbc.M110.104950
Asari, Kanemitsu, Kurihara
J Biol Chem (2010) 285 (32), 24751-8 DOI: 10.1074/jbc.M110.104950
AI Summary: In this study, OriGene's TLR4 shRNA lentiviral particles were used to generate TLR-4 knockdown HT29 cells, enabling the authors to demonstrate that high molecular weight hyaluronan (HA900) regulates immune responses in the intestinal epithelium specifically via TLR-4 signaling.
Showing 1-1 of 1 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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