LRP2 Mouse Monoclonal Antibody [Clone ID: CD7D5]
Specifications
| Product Data | |
| Clone Name | CD7D5 |
|---|---|
| Application | IF, IHC |
| Recommended Dilution | Immunofluorescence/Immunohistochemistry: 2-5 µg/ml. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Glycoprotein 330 membrane protein fraction of isolated human glomeruli |
| Specificity | This antibody recognizes Megalin/gp330. |
| Buffer | PBS without preservatives or stabilizers State: Purified State: Lyophilized purified IgG fraction |
| Reconstitution Method | Restore in sterile water to a concentration of 0.1-1.0 mg/ml. Centrifuge vial prior to opening. |
| Purification | Protein G Chromatography |
| Conjugation | Unconjugated |
| Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Gene Name | LDL receptor related protein 2 |
| Database Link | |
| Background | Megalin, also called Lipoprotein receptor-related protein-2 (LRP2) or glycoprotein 330, is a 600-kDa transmembrane protein belonging to the LDL-receptor family. Members of this receptor family are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Megalin was first discovered in 1982 as the pathogenic antigen of Heymann nephritis. The complete cDNA sequences have been characterized for rat and human Megalin. The protein contains a single transmembrane domain, is known to act as an endocytic receptor and is expressed primarily on the apical membrane domain of epithelial cells. Both the protein and its mRNA have been identified in human parathyroid cells, placental cytotrophoblasts and epididymal epithelial cells. The protein is also expressed in mammary epithelia, thyroid follicular cells, yolk sacs, the ciliary body of the eye, the intestinal brush border, the male reproductive tract, uterus and oviduct, and gallbladder epithelium. In addition, immortalised foetal rat alveolar pretype II cells, adult rat type II pneumocytes and human type II cells have all been reported to express megalin. It has been proposed that in adult lung megalin may be important in supplying vitamin E to type II pneumocytes. Specifically, Megalin mediates the uptake of apolipoprotein J, which is a binding protein for the beta-Amyloid peptide, a peptide implicated in Alzheimer's disease. It is also involved in renal uptake of Angiotensin and the reabsorption of various molecules including calcium, vitamin B12 and vitamin D. |
| Synonyms | Megalin, Glycoprotein 330, LRP-2 |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins, Membrane Proteins |
Reviews
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Citations
TIMP-2 and IGFBP7 in human kidney biopsies in renal disease
Schanz, Kimmel, Alscher et al
Clinical Kidney Journal (2023)
Schanz, Kimmel, Alscher et al
Clinical Kidney Journal (2023)
Cited by 27
AI Summary: In this study, OriGene products—specifically the anti-IGFBP7 antibody (TA500648) and anti-TIMP2 antibody (TA500494)—were used for immunohistochemical detection and localization of TIMP-2 and IGFBP7 expression in human kidney biopsy samples to assess their association with renal injury.
Snippet: against human CD31 (M0823;Dako Deutschland GmbH, Hamburg, Germany);megalin, a mouse monoclonal antibody to human megalin (DM3613P;Acris antibodies
Human Kidney-Derived Cells Ameliorate Acute Kidney Injury Without Engrafting into Renal Tissue
Santeramo, Herrera Perez, Illera et al
Stem Cells Transl Med (2017) 6 (5), 1373-1384 DOI: 10.1002/sctm.16-0352
Santeramo, Herrera Perez, Illera et al
Stem Cells Transl Med (2017) 6 (5), 1373-1384 DOI: 10.1002/sctm.16-0352
Cited by 44
AI Summary: OriGene products contributed to this study by providing anti-human mitochondria antibody (catalog number TA339316), which was used for immunohistochemical detection of human cells in rat kidney tissue to assess cell engraftment after transplantation.
Ex vivo modeling of chemical synergy in prenatal kidney cystogenesis
Anders, Ashton, Ranjzad et al
PLoS One (2013) 8 (3), e57797 DOI: 10.1371/journal.pone.0057797
Anders, Ashton, Ranjzad et al
PLoS One (2013) 8 (3), e57797 DOI: 10.1371/journal.pone.0057797
Cited by 10
AI Summary: OriGene products contributed to this paper by providing the specific tubule markers used for phenotyping, including the anti-AQP1 antibody (Cat# TA324403) and anti-SLC12A1 antibody (Cat# TA326082), which enabled the identification of affected kidney structures during cystogenesis analysis.
Showing 1-3 of 3 papers.
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