Granzyme K (GZMK) Mouse Monoclonal Antibody [Clone ID: GM6C3]
$520.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | GM6C3 |
|---|---|
| Application | ELISA, FC |
| Recommended Dilution | Flow cytometry: 1.2 µg/106 cells. ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Genetic immunisation with cDNA encoding human Granzyme K |
| Specificity | This antibody reacts to Granzyme K (GZMK). |
| Buffer | Phosphate buffered saline, pH 7.2 State: Purified State: Liquid purified Ig |
| Concentration | lot specific |
| Purification | Affinity chromatography on Protein G |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | granzyme K |
| Database Link | |
| Background | Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes. |
| Synonyms | Granzyme-3, NK-tryptase-2, Fragmentin-3, TRYP2, NK-Tryp-2 |
| Reference Data | |
| Protein Categories | Enzyme: Peptidases, Secreated Proteins |
Reviews
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Citations
Detection of soluble human granzyme K in vitro and in vivo
Bade, Lohrmann, ten Brinke et al
Eur J Immunol (2005) 35 (10), 2940-8 DOI: 10.1002/eji.200526249
Bade, Lohrmann, ten Brinke et al
Eur J Immunol (2005) 35 (10), 2940-8 DOI: 10.1002/eji.200526249
Cited by 63
AI Summary: OriGene products contributed to this study by providing the human granzyme K cDNA clone (OriGene, Cat# SC119270), which was used for the expression and detection of GzmK in ELISA assays and other analyses.
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