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IL13 receptor alpha 1 (IL13RA1) Mouse Monoclonal Antibody [Clone ID: GM1C8]

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SKU
DM1210
IL13 receptor alpha 1 (IL13RA1) mouse monoclonal antibody, clone GM1C8, Purified
Size:
100 ul
Conjugation:
Unconjugated
  $520.00
2 Weeks*
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View other "IL13RA1 or NP_001551.1" antibodies

Specifications
Specifications
Product Data
Clone Name GM1C8
Application ELISA, FC, IF
Recommended Dilution Flow cytometry: 1.2 µg/106 cells.
The antibody is routinely tested by on BOSC cells transiently transfected with an IL-13Rα1 expression vector.
Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
It is expected that the antibody will be suited for all applications where recognition of the native protein is required.
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen cDNA of the human IL-13Rα1 chain extracellular domain (U62858).
Specificity Clone GM1C8 recognises IL-13Rα1 transiently expressed on the cell surface of transfected BOSC cells as well as the native protein on monocytes (W. Luttmann, unpublished data).
Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
Buffer PBS, pH 7.2
State: Purified
State: Liquid purified IgG fraction
Preservative: 0.01% Sodium Azide
Concentration lot specific
Purification Protein G chromatography
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name interleukin 13 receptor subunit alpha 1
Database Link
Background Interleukin 13 (IL-13) is a T cell derived cytokine involved in the regulation of inflammatory and im-mune responses. IL-13Rα1 together with IL-4Rα forms a functional receptor for both IL-4 and IL-13, which is why these two cytokines share many of their biological activities. The receptor is found on human B cells, monocytes and endothelial cells. However, no functional receptor is expressed on T cells, which explains why IL-13, in contrast to IL-4, fails to induce TH2-cell differentiation.
Synonyms Interleukin-13 receptor alpha-1 chain, IL-13R-alpha-1, IL-13RA-1, IL13R, IL13RA, IL13 receptor alpha, CT19
Reference Data
Protein Categories CD Markers, Cytokines, Intracellular Proteins, Membrane Proteins
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Documents
Resources

file-alt Citations

Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor alpha1
Krause, Behrends, Borowski et al
Mol Immunol (2006) 43 (11), 1799-807 DOI: 10.1016/j.molimm.2005.11.001
Cited by 23
AI Summary: In this study, OriGene’s human IL-13Ralpha1 cDNA (Cat# SC119378) was used to generate cell lines overexpressing the IL-13Ralpha1 receptor, enabling the authors to screen and validate the specificity and inhibitory function of novel monoclonal antibodies targeting human IL-13Ralpha1.
Expression of CD13/aminopeptidase N on human gingival fibroblasts and up-regulation upon stimulation with interleukin-4 and interleukin-13
Kunii, Nemoto, Kanaya et al
J Periodontal Res (2005) 40 (2), 138-46 DOI: 10.1111/j.1600-0765.2004.00778.x
Cited by 13
AI Summary: In this study, OriGene’s CD13/APN antibody (catalog #TA328277) was used for flow cytometry to assess protein expression, contributing to the identification and quantification of CD13/APN on human gingival fibroblasts.
Showing 1-2 of 2 papers.
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