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CD66a/b/c/e Mouse Monoclonal Antibody [Clone ID: TET2]

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SKU
DM1205
CD66a/b/c/e mouse monoclonal antibody, clone TET2, Purified
Size:
100 ug
Conjugation:
Unconjugated
  $520.00
2 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Clone Name TET2
Application ELISA, FC, IF, IHC, WB
Recommended Dilution Flow Cytometry: 1.0 µg/106 cells.
ELISA: 1/200-1/400.
Cell based ELISA with intakt, transiently transfected cells: 1/200.
Western Blot: 4 µg/ml.
Immunohistology: 1-2 µg/106 cells (on Cryosections).
Reactivity Human
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen TET2 was generated by immunisation of BALB/c mice with CEA partially purified from a perchloric acid extract from liver metastases of colonic tumors (3).
Specificity This antibody recognizes CD66a/b/c/e.
Buffer Phosphate buffered saline, pH 7.2
State: Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Affinity Chromatography on Protein G
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Background CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). The CEA family proteins belong to the immuno-globulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Synonyms CEACAM1, CEACAM5, CEACAM6, CEACAM8, BGP, CD66a, CD66b, CD66c, CD66d
Note Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
Reference Data
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Documents
Resources

file-alt Citations

Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site
Watt, Teixeira, Zhou et al
Blood (2001) 98 (5), 1469-79 DOI: 10.1182/blood.v98.5.1469
Cited by 107
AI Summary: OriGene’s human CEACAM1 cDNA clone (Cat# SC119099) was used to generate mutant CEACAM1 constructs for functional and structural analyses in this study.
Showing 1-1 of 1 papers.
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