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PSMA (FOLH1) Mouse Monoclonal Antibody [Clone ID: Y-PSMA1]

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SKU
DM1037
PSMA (FOLH1) mouse monoclonal antibody, clone Y-PSMA1, Purified
Size:
500 ug
Conjugation:
Unconjugated
  $715.00
2 Weeks*
Bulk/Customize

View other "FOLH1 or NP_001014986.1" antibodies

Specifications
Specifications
Product Data
Clone Name Y-PSMA1
Application ELISA, IF, IHC, WB
Recommended Dilution ELISA.
Western blot: 1.0 µl/ml, Indentified the 100 kDa PSMA in LNcap cell extract.
Immunofluorescence.
Immunohistochemistry on Formalin-Fixed Paraffin Embedded and Frozen Tissue Sections.
Reactivity Human
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Crude membrane protein preparation from pooled prostate malignant carcinoma.
Specificity This antibody detects PSMA expressed LNCap cell lines.
Little or no cross-reactivity to benign prostate hyperplasia (BPH) or to normal prostatic tissue.
Buffer 0.01M PBS, pH 7.0
State: Purified
State: Lyophilized purified IgG fraction
Stabilizer: None
Preservative: None
Reconstitution Method Restore with double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification Affinity Chromatography on Protein G
Conjugation Unconjugated
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Gene Name folate hydrolase (prostate-specific membrane antigen) 1
Database Link
Background PSMA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.
Synonyms Glutamate carboxypeptidase 2, Folate hydrolase 1, Prostate-specific membrane antigen, FOLH, NAALAD1, PSM, GCP2, NAALAdase
Note Predicted Molecular weight: 84 kDa.
Reference Data
Protein Categories ADC Targets, CAR-T Targets, Enzyme: Peptidases, Intracellular Proteins, Membrane Proteins, Secreated Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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