CDC25B Mouse Monoclonal Antibody [Clone ID: OTI11C5]
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI11C5 |
|---|---|
| Application | WB |
| Recommended Dilution | WB 1:2000 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 421-567 of human CDC25B (NP_004349) produced in E.coli. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Gene Name | cell division cycle 25B |
| Database Link | |
| Background | CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. provided by RefSeq, Jul 2008 |
| Reference Data | |
| Protein Categories | Cytokines, Intracellular Proteins |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | Cell cycle, MAPK signaling pathway, Progesterone-mediated oocyte maturation |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI11C5" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA812342 | CDC25B mouse monoclonal antibody,clone OTI11C5 | 100 ul |
$447.00
|
|
| TA812342AM | CDC25B mouse monoclonal antibody,clone OTI11C5, Biotinylated | 100 ul |
$509.00
|
|
| TA812342BM | CDC25B mouse monoclonal antibody,clone OTI11C5, HRP conjugated | 100 ul |
$509.00
|
|
| TA812342S | CDC25B mouse monoclonal antibody,clone OTI11C5 | 30 ul |
$200.00
|
|
Citations
A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression
Poudyal, Herman, Adelsberger et al
Sci Rep (2018) 8 (1), 900 DOI: 10.1038/s41598-018-19259-4
Poudyal, Herman, Adelsberger et al
Sci Rep (2018) 8 (1), 900 DOI: 10.1038/s41598-018-19259-4
AI Summary: OriGene products contributed to this study by providing anti-Cdc25B antibody and siRNAs targeting FoxM1, B-Myb, FoxO3a, and a negative control, which were used to investigate the molecular mechanisms underlying miR-6852-induced cell cycle arrest and necrosis in cervical cancer cells.
Snippet: Anti-Cdc25B was obtained from Origene. Anti-AuroraK B and Anti-Plk1 were obtained from Cell Signaling. Anti-Cyclin A1 and Anti-Cdc25c were obtained from Millipore. Si-RNA against FoxM1, B-Myb, FoxO3a and Negative control siRNA were obtained from Origene
Showing 1-1 of 1 papers.
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