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NOTCH1 Mouse Monoclonal Antibody [Clone ID: OTI2E7]

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SKU
CF808308
Carrier-free (BSA/glycerol-free) NOTCH1 mouse monoclonal antibody, clone OTI2E7 (formerly 2E7)
Size:
100 ug
Formulation:
Carrier-free Standard
Conjugation:
Unconjugated
  $620.00
3 Days*
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View other "NOTCH1 or NM_017617" antibodies

Specifications
Specifications
Product Data
Clone Name OTI2E7
Application IHC
Recommended Dilution IHC 1:150
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 2280-2556 of human NOTCH1(NP_060087) produced in E.coli.
Buffer Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Predicted Protein Size 270.6 kDa
Gene Name notch receptor 1
Database Link
Background This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. provided by RefSeq, Jul 2008
Synonyms AOS5; AOVD1; hN1; TAN1
Reference Data
Protein Categories Cancer: Gynecologic, Cancer: Haematopoietic and Lymphoid, CAR-T Targets, Growth Factors, Membrane Proteins
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway
Protein Pathways Dorso-ventral axis formation, Notch signaling pathway, Prion diseases
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Other "OTI2E7" antibodies (4)
SKU Description Size Price
TA808308 NOTCH1 mouse monoclonal antibody, clone OTI2E7 (formerly 2E7) 100 ul
$447.00
TA808308AM NOTCH1 mouse monoclonal antibody, clone OTI2E7 (formerly 2E7), Biotinylated 100 ul
$509.00
TA808308BM NOTCH1 mouse monoclonal antibody, clone OTI2E7 (formerly 2E7), HRP conjugated 100 ul
$509.00
TA808308S NOTCH1 mouse monoclonal antibody, clone OTI2E7 (formerly 2E7) 30 ul
$200.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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