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Factor I (CFI) Mouse Monoclonal Antibody [Clone ID: OTI4A8]

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SKU
CF806031
Carrier-free (BSA/glycerol-free) CFI mouse monoclonal antibody, clone OTI4A8 (formerly 4A8)
Size:
100 ug
Formulation:
Carrier-free Standard
Conjugation:
Unconjugated
  $620.00
3 Days*
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View other "Factor I or NM_000204" antibodies

Specifications
Specifications
Product Data
Clone Name OTI4A8
Application IHC, WB
Recommended Dilution WB 1:2000
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 340-583 of human CFI(NP_000195) produced in E.coli.
Buffer Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Predicted Protein Size 63.4 kDa
Gene Name complement factor I
Database Link
Background This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. provided by RefSeq, Jul 2008
Synonyms AHUS3; ARMD13; C3b-INA; C3BINA; FI; IF; KAF
Reference Data
Protein Categories Cardiovascular diseases, Enzyme: Peptidases, Immune system diseases, Nervous system Diseases, Secreated Proteins
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades
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Other "OTI4A8" antibodies (4)
SKU Description Size Price
TA806031 CFI mouse monoclonal antibody, clone OTI4A8 (formerly 4A8) 100 ul
$447.00
TA806031AM CFI mouse monoclonal antibody, clone OTI4A8 (formerly 4A8), Biotinylated 100 ul
$509.00
TA806031BM CFI mouse monoclonal antibody, clone OTI4A8 (formerly 4A8), HRP conjugated 100 ul
$509.00
TA806031S CFI mouse monoclonal antibody, clone OTI4A8 (formerly 4A8) 30 ul
$200.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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